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Deanship of Scientific Research
Document Details
Document Type
:
Project
Document Title
:
Maternal biochemical markers and maternal fetal nucleic acids for screening of fetal aneuploidy and adverse pregnancy outcomes: a prospective study
استخدام الواسمات الكيموحيوية والأحماض النووية الجينية الأمومية للتعرف على اختلاطات الحمل ونتائجه المعاكسة
Subject
:
Maternal biochemical markers and maternal fetal nucleic acids for screening of fetal aneuploidy and adverse pregnancy outcomes: a prospective study
Document Language
:
Arabic
Abstract
:
There are several prenatal screening programmes currently in practice in both Europe and North America using maternal biochemical markers and ultrasonography. Several studies have reported racial differences in the use of such markers and investigators reported differences between Caucasian and Asian populations. Unfortunately, no information is available in the literature in relation to the use of these markers during the course of prenatal care in Saudi Arabian population. Recently, molecular analysis of plasma nucleic acids during human pregnancy has led to the discovery that maternal plasma contains both fetal DNA and fetal RNA. The detection of fetal nucleic acids in maternal plasma is much simpler and more robust than detecting fetal nucleated cells in maternal blood, and does not require prior enrichment. This approach may also have application in the prenatal diagnosis of fetal abnormalities and/or adverse pregnancy outcomes. Thus, the main objectives of the present proposed research project are to establish, in the local population of pregnant women, the reference values of first and second trimesters biochemical markers [namely: α-fetoprotein (AFP), unconjugated oesteriol (uE3), human chorionic gonadotrophin (hCG), free β-hCG, inhibin-A (In-A), pregnancy associated plasma protein-A (PAPP-A) and fetal nuchal translucency thickness (fetal-NT) together with that of maternal fetal DNA and fetal RNA used for prenatal screening of fetal aneuploidies and other adverse pregnancy outcomes. In addition, the value of such markers and the efficacy of their use in relation to adverse pregnancy outcomes in the local population will also be evaluated. The duration of this project is 20 months.
Publishing Year
:
1428 AH
2007 AD
Sponsor Name
:
King Abdulaziz University
Sponsorship Year
:
1428 AH
2007 AD
Added Date
:
Sunday, June 27, 2010
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
محمد العرضاوي صالح العرضاوي
Al-Ardaw, Mohammed ٍSaleh
Investigator
Doctorate
Files
File Name
Type
Description
27151.docx
docx
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