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Document Type |
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Thesis |
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Document Title |
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THE EFFECT OF CORN SILK AQUEOUS EXTRACT ON THE EMBRYOS OF DIABETIC PREGNANT MICE تأثير المستخلص المائي لشعيرات الذرة على أجنة الفئران الحوامل المصابة بالسكر |
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Subject |
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Faculty of Science |
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Document Language |
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Arabic |
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Abstract |
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Diabetes is an increasing health problem which could increase the rate of congenital malformations. One of the natural hypoglycemic treatments that had been used is Corn Silk extract. In this study, we examined the effect of Corn Silk aqueous extract on E16.5 embryos, neonates, and offspring (3 weeks postnatal) of diabetic female mice. Female mice were divided into four groups: Control, Treated, Diabetic Control, and Diabetic Treated. Pregnant mice of treated groups were given a daily dose of 4 g/kg of the extract orally, while mice of control groups were given equal amounts of distilled water. Samples were collected at day 16.5 of pregnancy, birth (neonates), and 3 weeks postnatal. Whole body weight and length in addition to tail length were measured, and morphological malformations were recorded. Brown adipose tissue in the sections of preserved samples were examined. The rate of malformations in embryos of diabetic mothers was not decreased when Corn Silk extract was administered (4g/kg), but in 3 weeks postnatal mice of treated mothers a significant increase in whole body weight and length was observed. The most prevalent defect seen was intrauterine growth retardation, two cases of exencephaly, and a case of caudal defect. The brown adipose tissue areas were negatively affected by diabetes and the extract. Both the extract and diabetes caused an increase in fat accumulation in the adipocytes with varying degrees. It was concluded that Corn Silk consumption during pregnancy might not be favorable, in the dose used, while it might have some benefits if used while nursing (in the lactation period). More studies with deferent doses are needed. Also, the effect of the extract on lactation and nursing milk composition should be investigated. |
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Supervisor |
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Dr. Fatma Alqudsi |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1443 AH
2022 AD |
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Added Date |
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Friday, January 6, 2023 |
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Researchers
| ديمه مساعد السديري | Alsudairi, Dema Musaid | Researcher | Master | |
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