Document Details

Document Type : Thesis 
Document Title :
The Role of ACSF3 Protein as a Putative Biomarker in Saudi Autistic Children
دور بروتين ACSF3 كمؤشر حيوي محتمل لدى أطفال التوحد السعوديين
 
Subject : Faculty of Science 
Document Language : Arabic 
Abstract : Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with a prevalence rate of 1-2% of the general population. Although many research showed the impact of the genetic in ASD, there are many studies that pointed the role of epigenetic dysregulation in ASD. According to the ongoing research conducted by the autism team in the biological department-faculty of science-KAU, many genes have shown a critical difference in the methylation state between the Saudi autistic children compared to their normal siblings, one of these genes is Acyl-CoA synthetase family member 3, mitochondrial (ACSF3). In this study, immunoblotting techniques (ELISA, and western immunoblotting) were performed to examine ACSF3 protein expression in Saudi autistic children and their normal siblings. A significant difference in ACSF3 protein expression has been appeared between autistic children compared to their normal sibling, which indicates that ACSF3 associated with ASD. This study predicted the 3D structure of ACSF3 -by using bioinformatics tools- to illustrate the role of ACSF3 in ASD. Mitochondrial energy metabolism impairments caused by malonate associated with many neurodegenerative disorders. Since ACSF3 is important in malonate detoxification, we suggested that ACSF3 may play role in ASD. Consequently, ACSF3 may be considered a potential biomarker for Saudi autistic children. 
Supervisor : Dr. Mona G. Alharbi 
Thesis Type : Master Thesis 
Publishing Year : 1443 AH
2022 AD 
Co-Supervisor : Dr. Magdah A. Ganash 
Added Date : Monday, December 26, 2022 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
ندى عبدالصمد المرغلانيAlMarghalani, Nada AbdulsamadResearcherMaster 

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