Document Details
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Document Type |
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Thesis |
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Document Title |
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Detection of SNPs associated with preeclampsia susceptibility in Saudi women. الكشف عن تعدد أشكال النيوكليتيدة المرتبطة بقابلية تسمم الحمل لدى النساء السعوديات |
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Subject |
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Faculty of Sciences |
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Document Language |
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Arabic |
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Abstract |
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Preeclampsia (PE) remains a major cause of maternal morbidity and mortality worldwide. The etiology of preeclampsia is still unknown. Growing studies reveal the association between several single-nucleotide polymorphisms (SNPs) and PE susceptibility; however, the results are inconsistent at the population level. Recent meta analysis and systemic reviews of candidate association studies indicate the involvement of four SNPs (rs1051740, rs2234922, rs268, and rs6025) in preeclampsia development.
Both rs1051740 and rs2234922 are located within microsomal epoxide hydrolase1, (EPHX1), whereas rs268 and rs6025 are in the lipoprotein lipase (LPL) and Factor V Leiden (F5), respectively, which were chosen as the subject of this study.
OBJECTIVE:
This work aims to select putative PE associated SNPs and evaluate the association of these selected SNPs with PE among Saudi women.
METHODS:
Blood samples of 139 healthy pregnant and 94 preeclamptic Saudi women are collected, and DNA extracted, followed by genotyping using Real-Time PCR with hydrolysis probe (TaqMan® life Technologies).
RESULTS:
The results showed no significant associations between genotypes and preeclampsia development for the four SNPs studies (OR= 1.126; 95 % CI= 0.6624-1.9147; p=0.66, for rs1051740, OR=1.098; 95 % CI=0.62-1.94; p=0.75, for rs2234922, OR=1; 95 % CI=0.69-1.45; p=1, for rs268, OR= 1; 95 % CI=0.69-1.45; p= 1, for rs6025) in Saudi women.
CONCLUSIONS:
It seems that four SNP (rs1051740, rs2234922, rs268, and rs6025) are not important candidates for the development of preeclampsia in Saudi women. Importantly, there is a critical need to determine other genetic variants that influence the risk of PE in Saudi population, which can provide potential biomarkers in the early diagnosis of this disease. |
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Supervisor |
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Dr. Nouf Laqtom |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1438 AH
2017 AD |
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Co-Supervisor |
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Prof. Nabeel Bondagji |
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Added Date |
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Monday, August 21, 2017 |
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Researchers
| ندى محمد الجعيد | Aljuaid, Nada Mohammed | Researcher | Master | |
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