Document Details
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Document Type |
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Thesis |
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Document Title |
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Assessment of antidiabetic and antioxidant activities of Cassia angustifolia and Feoniculum vulgare in diabetic rats. تقييم مضاد السكري والأنشطة المضادة للأكسدة للسنا و السنوت في الجرذان المصابة بالسكري |
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Subject |
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Faculty of Sciences |
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Document Language |
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Arabic |
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Abstract |
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Diabetes mellitus (DM) has become one of the most challenging health problems of the 21st century. It is associated with a number of different metabolic abnormalities. The use of herbs as medicines has increasedworld wide. maintaining the target glucose level and modulating the oxidative stress associated with DM would be an alternative approach to manag DM complications. The present work was conducted to test the hypothesis that combined treatment with aqueous extract of Cassia angustifolia (AECA) and Feoniculum vulgar(AEFV) is more effective than each of them alone in improving the severity of DM and oxidative stress in streptozotocin-induced diabetic male rats. Diabetes was induced in male albino rats by an intraperitoneal injection of a single dose of streptozotocin (60 mg/kg body) . Fifty male albino rats, weighing 150-200 g, were divided into five groups, namely control, diabetic and diabetic rats received either AECA (150 mg/kg /day ), or AEFV (150mg/kg/day) and their combination by gastric intubation for 4 weeks. Diabetic rats exhibited many symptoms, including loss of body weight, hyperglycemia, decreases in serum insulin, and high density lipoprotein-cholesterol levels, elevated triglycerides, total cholesterol , low density lipoprotein-cholesterol concentrations and liver marker enzymes. Significant increase in TBARS,(lipid peroxidation marker) was observed in diabetic liver and pancreas. This was accompanied by a significant decrease in GSH ,GPx content, SOD and CAT activity of the liver and pancreas. Daily oral ingestion of AECA and/or AEFV extract for 4weeks after diabetes induction ameliorated hyperglycemia, increased insulin, improved lipid profiles, restored body weight loss and liver function, blunted the increased in MDA, modulated the levels of hepatic and pancreatic SOD and CAT activities and GSH content. It could be suggested that each of AECA and /or AEFV could be used as an antidiabetic compliment in case of DM. This may be related to their antioxidative properties. |
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Supervisor |
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Dr: Nadia Nour Osman |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1438 AH
2017 AD |
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Added Date |
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Tuesday, July 11, 2017 |
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Researchers
| ندى حسين عسيري | asiri, Nada hussain | Researcher | Master | |
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