Document Details

Document Type : Thesis 
Document Title :
Effect of Pineapple (Ananas Comosus L.) Leaves Extract on Hypercholesterolemic Male Rats
تأثير مستخلص ورقة الاناناس على خفض دهون الدم عند ذكورالجرذان
 
Subject : Faculty of Home Economics 
Document Language : Arabic 
Abstract : Objective: The present study aim to investigate the quantification and identification of phenolic compounds of Pineapple (Ananas comosus L.) Leaves Extract (PLE) and evaluate the effect of oral administration of PLE at different doses on hypercholesterolemia male rats after 4 weeks of treatment on body weight gain% (BWG%), feed efficiency ratio (FER) and relative weight of liver, serum levels of total cholesterol (TC), triglycerides (TG), atherogenic index (AI), lipoprotein fractions and Glucose and insulin concentration were performed. Histopathological examination of liver was also studied. Methods: Thirty male albino rats of Wistar strain were distributed into five groups as follows: group1: negative control group, group 2: positive control (hypercholesterolemia rats) group, groups 3, 4 and 5 fed on High cholesterol and high fat diet and treated with orally doses of PLE of 250, 500 and 750mg/kg b. wt., respectively. Results: The results showed that, the total content of phenolic compound of pineapple leaves extract was 22.28 mg/100 ml. The phenolic compound were separated based on their functional groups into 25 fractions and identified 24 compounds from them by HPLC. The oral intake of PLE to hypercholesterolemia rats for 4 weeks significantly decreased serum levels of TC, TG, LDL-c, VLDL-c, AI and Glucose concentration when compared to the control positive group. Levels of HDL-c and insulin concentration were significantly increased as compared to the control positive group. Histopathological examination of liver sections of rats of PLE -treated groups showed amelioration of histological changes caused by high level of cholesterol in the positive control group. Conclusion: There is a potent antiatherogenic and antioxidant effects for PLE on hypercholesterolemia rats. This study recommends that intake of PLE may be beneficial for patients who suffer from hypercholesterolemia and/or arteriosclerosis. Key words: Pineapple leaves, Pineapple Ananas comosus L., Lipid profile, rats Hypercholesterolemia, body weight gain% (BWG %), feed efficiency ratio (FER).‎ 
Supervisor : Dr. Amani Alawi Awad Al-Rasheedi 
Thesis Type : Master Thesis 
Publishing Year : 1438 AH
2016 AD 
Co-Supervisor : Dr. Maha Ahmad Hassan Hejazi 
Added Date : Thursday, December 22, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
لما محمد بيت المالBait Almal, Lama MohammedResearcherMaster 

Files

File NameTypeDescription
 39532.pdf pdf 

Back To Researches Page