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Document Type |
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Thesis |
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Document Title |
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Structure Elucidation of Bioactive Natural Compounds from Red Algae of Saudi Arabia Red Sea Coast إثبات التركيب الكيميائي والنشاط الحيوي للمركبات الطبيعية المفصولة من الطحالب الحمراء لشواطىء البحر الأحمر السعودية |
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Subject |
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Chemistry department |
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Document Language |
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Arabic |
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Abstract |
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Three new sesquiterpene alcohols; laur-2-en-3, 12-diol (10), 3, 12-dihydroxy cuparene (7) and 8, 11 dihydro-1-methoxy-12-hydroxy cuparene. (8), along with one known diterpene, 10-hydroxykahukuene (9),four known C15- acetogenins; (12E) Cis-Maneonene-A (2), (12Z)-Cis-Maneonene-D (3), (12E)-Cis-Maneonene-E (4) and (12Z)-Trans-maneonene-C (5) and two known sesquiterpene; 2,10-dibromo-3-chloro-α-chamigrene.(1) and 12-hydroxy isolaurene.(6) were isolated from the methylene chloride/methanol (1:1) extract of the red alga Laurencia obtusa. The chemical structures were elucidated on the basis of spectroscopic analysis. The cytotoxicity of the isolated compounds was evaluated against three tumor human cell lines. Compound (9) revealed to possess a wide range of antitumor activity against epidermoid nasopharynx carcinoma (KB), hepatoma (HepG2), and breast cancer (MCF-7) cell lines with IC50 at 46.2, 26.2, and 25.2(µg/ml), respectively. However, compound (10) showed moderate activity towards KB and MCF-7 cells (IC50 = 39.8, 42.8 µg/ml, respectively). Compound (7) exhibited moderate activity against KB cells (IC50 = 49.8 µg/ml) and compound (8) showed almost no activity against the tested three cell lines (IC50 µg/ml >100 ). |
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Supervisor |
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Prof. Dr. Seif-Eldin N. Ayyad |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1434 AH
2013 AD |
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Co-Supervisor |
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Dr. Rihab F. Angawi |
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Added Date |
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Tuesday, June 18, 2013 |
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Researchers
| رحاب اسماعيل حمزه | Hamza, Rehab Ismail | Researcher | Master | |
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