Document Details

Document Type : Article In Journal 
Document Title :
Impact of hypertension, smoking and liver affection on endothelial dysfunction and subsequent vascular damage in Saudi middle aged males
تاثير ارتفاع ضغط الدم , والاصابة الكبدية على خلل الخلايا البطانية وتدمير الاوعية الدموية في الذكور السعوديين متوسطي العمر
 
Subject : Impact of hypertension, smoking and liver affection on endothelial dysfunction and subsequent vascular damage in Saudi middle aged males 
Document Language : English 
Abstract : Endothelial dysfunction is one of the mechanisms linked to an increased risk of cardiovascular disease. To assess the impact of hypertension, smoking and past history of schistosomiasis on endothelial dysfunction and vascular damage in Saudi middle aged males who don’t exercise regularly, the levels of soluble adhesion molecules E-selectin, ICAM-1 and VCAM-1, biomarkers of the activation of inflammatory cascades during the development of vascular injury, were determined. Plasma levels of sVCAM-1, sICAM-1 and sE-selectin were found to be elevated as a result of hypertension and/or cigarette smoking compared to normal counterparts. These results demonstrated that hypertension and cigarette smoking had the strongest direct associations with these biomarkers which are a reflection of their effect on endothelial dysfunction and subsequent vascular damage, while a past history of schistosomiasis had very little association with these biomarkers. These results also suggest that sVCAM-1 may be useful in assessing the impact of liver affliction, (as a result of schistosomiasis) on endothelial dysfunction. 
ISSN : 1214-0287 
Journal Name : journal of applied biomedicine 
Volume : 5 
Issue Number : 1 
Publishing Year : 1428 AH
2007 AD 
Article Type : Article 
Added Date : Sunday, February 3, 2013 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
خالد عمر ابو النجاABUALNAJA, KHALED OMERResearcherDoctorateKABUALNAJA@KSA.EDU.SA

Files

File NameTypeDescription
 34959.pdf pdfبحث طبي يناقش تاثير ارتفاع ضغط الدم

Back To Researches Page