Main Page
Deanship
The Dean
Dean's Word
Curriculum Vitae
Contact the Dean
Vision and Mission
Organizational Structure
Vice- Deanship
Vice- Dean
KAU Graduate Studies
Research Services & Courses
Research Services Unit
Important Research for Society
Deanship's Services
FAQs
Research
Staff Directory
Files
Favorite Websites
Deanship Access Map
Graduate Studies Awards
Deanship's Staff
Staff Directory
Files
Researches
Contact us
عربي
English
About
Admission
Academic
Research and Innovations
University Life
E-Services
Search
Deanship of Graduate Studies
Document Details
Document Type
:
Thesis
Document Title
:
Study of Mutagenic Effect of Carboplatin on Somatic and Germinal Cells of Male Albino Mice
دراسة التأثير المطفر لعقار الكاربوبلاتين على الخلايا الجسدية والجرثومية لذكور الفئران البيضاء
Subject
:
biological sciences department
Document Language
:
Arabic
Abstract
:
Genotoxicity of carboplatin was assayed in somatic and germ cells of adult male swiss albino mice, Mus musculus.Genotoxicity and cytotoxicity was evaluated by micronucleus test and sperm-head abnormalities test. Three doses were used, a sub - cute therapeutic dose (2mg\kg), double the therapeutic dose (4mg\kg) and five times the therapeutic dose (10mg\kg) . Mice has been treated in each of the micronucleus test and sperm-head abnormalities test for five consecutive days by injection into the intraperitonealinjection. Results showedsignificantincreasein the micronucleus test on bone marrow also in the sperm-head abnormalities test in two stages: Late spermatids and Secondary spermatocytes. The overall results suggest a positive relationship between dose and occurrence of both micronucleus test in bone marrow and sperm -head abnormalities test. From this, the ability of the drug mutagenicity can be concluded. This mutagenic strength can access to somatic and germ cell which give the ability of transmition to the next generations.
Supervisor
:
Dr. Salwa Mohammad Quita
Thesis Type
:
Master Thesis
Publishing Year
:
1433 AH
2012 AD
Co-Supervisor
:
Dr. Mohammed Zainy Mutawakal
Added Date
:
Tuesday, July 10, 2012
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
بدرية عبدالله حفني
Hifni, Badriah Abdullah
Researcher
Master
Files
File Name
Type
Description
33912.pdf
pdf
Back To Researches Page