Document Details Document Type : Article In Journal  Document Title : Chiral recognition of amino acids by use of a fluorescent resorcinarene Chiral recognition of amino acids by use of a fluorescent resorcinarene   Subject : Chemistry  Document Language : English  Abstract : The spectroscopic properties of a chiral boronic acid based resorcinarene macrocycle employed for chiral analysis were investigated. Specifically, the emission and excitation characteristics of tetraarylboronate resorcinarene macrocycle (TBRM) and its quantum yield were evaluated. The chiral selector TBRM was investigated as a chiral reagent for the enantiomeric discrimination of amino acids using steady-state fluorescence spectroscopy. Chiral recognition of amino acids in the presence of the macrocycle was based on diastereomeric complexes. Results demonstrated that TBRM had better chiral discrimination ability for lysine as compared to the other amino acids. Partial least squares regression modeling (PLS-1) of spectral data for macrocycle-lysine guest-host complexes was used to correlate the changes in the fluorescence emission for a set of calibration samples consisting of TBRM in the presence of varying enantiomeric compositions of lysine. In addition, validation studies were performed using an independently prepared set of samples with different enantiomeric compositions of lysine. The results of multivariate regression modeling indicated good prediction ability of lysine, which was confirmed by a root mean square percent relative error (RMS% RE) of 5.8%.  ISSN : 0003-7028  Journal Name : Applied Spectroscopy  Volume : 62  Issue Number : 5  Publishing Year : 1429 AH 2008 AD  Article Type : Article  Added Date : Monday, February 13, 2012  Researchers Researcher Name (Arabic) Researcher Name (English) Researcher Type Dr Grade Email Gerald I Richard Richard, Gerald I Researcher Doctorate   هادي محمد مرواني Marwani, Hadi Mohammed Researcher Doctorate hmarwani@kau.edu.sa Shan Jiang Jiang, Shan Researcher Doctorate   Sayo O Fakayode Fakayode, Sayo O Researcher     Mark Lowry Lowry, Mark Researcher Doctorate   Robert M Strongin Strongin, Robert M Researcher Doctorate strongin@pdx.edu Isiah M Warner Warner, Isiah M Researcher Doctorate iwarner@lsu.edu Files File Name Type Description  32270.pdf pdf Abstract Back To Researches Page