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Faculty of Medicine
Document Details
Document Type
:
Article In Journal
Document Title
:
Plasma and red blood cells membrane lipid concentration of sickle cell disease patients
Plasma and red blood cells membrane lipid concentration of sickle cell disease patients
Subject
:
Biochemistry
Document Language
:
English
Abstract
:
OBJECTIVE: The present study aimed to determine the concentration of plasma and red blood cells (RBCs) membrane lipids in Saudi sickle cell disease (SCD) patients. METHODS: This study was carried out at the Hematology Clinic, King Abdul-Aziz University Hospital, Jeddah, Kingdom of Saudi Arabia from October 1998 to October 1999. Lipid concentrations were determined in plasma and RBC membrane of 81 SCD patients and 66 normal healthy matched individuals (control). Different lipid parameters were measured according to standardized enzymatic assay methods. RESULTS: The plasma concentrations of total cholesterol and low density lipoprotein cholesterol of SCD patients were significantly decreased (p<0.001), whereas the plasma concentrations of high density lipoprotein phospholipids were significantly increased (p<0.001). The plasma concentrations of apo A and apo B were significantly decreased (p<0.001) in SCD patients. However, the concentration of total cholesterol of RBC membrane was significantly increased (p<0.001) in SCD patients, while the phospholipid content was significantly decreased (p<0.001). CONCLUSION: The significant increase of RBC membrane cholesterol concentration in SCD patients possibly is responsible to the change in RBC membrane fluidity that may play a direct role in the sickling phenomenon of RBCs in SCD
ISSN
:
0379-5284
Journal Name
:
The Saudi Medical Journal
Volume
:
24
Issue Number
:
4
Publishing Year
:
1424 AH
2003 AD
Article Type
:
Article
Added Date
:
Friday, December 2, 2011
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
زهير المرزوقي
Marzouki, Zohair
Investigator
Doctorate
Files
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Type
Description
31479.pdf
pdf
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