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Document Details
Document Type
:
Article In Journal
Document Title
:
Glucose and glutamine metabolism in the small intestine of septic rats
Glucose and glutamine metabolism in the small intestine of septic rats
Subject
:
Biochemistry
Document Language
:
English
Abstract
:
The intestinal metabolism of glucose and glutamine was studied in rats made septic by cecal ligation and puncture technique. Sepsis resulted in negative nitrogen balance and produced increases in the concentrations of blood pyruvate, lactate, alanine, and glutamine, and decreases in those of 3-hydroxybutyrate and acetoacetate. Both plasma insulin and glucagon concentrations were increased by 2.2- and 3.2-fold in septic rats, respectively. Portal-drained visceral blood flow increased in septic rats, and was accompanied by a decrease in the rates of utilization of glutamine and production of lactate, glutamate, and ammonia compared with those rates in sham-operated animals. Enterocytes isolated from septic rats showed decreased rates of glucose and glutamine utilization compared with cells isolated from corresponding controls. The maximal activities of hexokinase, 6-phosphofructokinase, pyruvate kinase, and glutaminase were decreased in intestinal mucosal scrapings of septic rats. It is concluded that a moderate form of sepsis decreases the rates of glucose and glutamine utilization (both in vivo and in vitro) by the epithelial cells of the small intestine. This may be caused by changes in the maximal activities of key enzymes in the pathways of glucose and glutamine metabolism in these cells as a metabolic adaptation to spare glucose and glutamine for use by other tissues
ISSN
:
0022-2143
Journal Name
:
The Journal of Laboratory and Clinical Medicine
Volume
:
115
Issue Number
:
6
Publishing Year
:
1410 AH
1990 AD
Article Type
:
Article
Added Date
:
Thursday, November 24, 2011
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
محمد العرضاوي
Ardawi, Mohammed
Investigator
Doctorate
ياسر جمال
Jamal, Yasir
Researcher
Doctorate
عبدالرحمن آشي
Ashy, AbdulRahman
Researcher
Doctorate
Files
File Name
Type
Description
31318.pdf
pdf
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