Main Page
Deanship
The Dean
Dean's Word
Curriculum Vitae
Contact the Dean
Vision and Mission
Organizational Structure
Vice- Deanship
Vice- Dean
KAU Graduate Studies
Research Services & Courses
Research Services Unit
Important Research for Society
Deanship's Services
FAQs
Research
Staff Directory
Files
Favorite Websites
Deanship Access Map
Graduate Studies Awards
Deanship's Staff
Staff Directory
Files
Researches
Contact us
عربي
English
About
Admission
Academic
Research and Innovations
University Life
E-Services
Search
Deanship of Graduate Studies
Document Details
Document Type
:
Thesis
Document Title
:
The prevalence of thrombophilic genes mutations in women with recurrent spontaneous abortion in Saudi population
انتشار طفرات مورثات تخثرالدم لدى النساء المصابات بالاجهاض التلقائي المتكرر في السعودية
Subject
:
Biochemistry department
Document Language
:
Arabic
Abstract
:
Factor V G1691A, prothrombin G20210A and MTHFR C677T are major inherited thrombophilia. Recently, a possible relationship between inherited thrombophilia and recurrent spontaneous abortion has been suggested. Most inherited thrombophilic cases remains asymptomic and the presence of a hypercoagulable state, like pregnancy, acts as a trigger to initiate clot formation in placenta which results in pregnancy complications, still birth and abortion. The aim of this study was to determine the frequency and prevalence of the thrombophilic mutations (FVL, prothrombin and MTHFR) in Saudi women diagnosed with unexplained recurrent spontaneous abortion (RSA). Forty six women diagnosed with unexplained recurrent abortion (age between 20-35 years) was compared with forty two women with uncomplicated pregnancy. The DNA was extracted from peripheral blood for all samples. Genotype analysis for the three mutations: factor V G1691A, prothrombin G20210A and MTHFR C677T were determined by PCR and RFLP using Mnl I, HindIII and HinfI restriction enzymes digestion, respectively. Mutation frequencies were (2.2% vs. 0%) for Factor V G1691A, (0% versus 2.2%) for prothrombin G20210A and (21.3% vs. 31%) for MTHFR in RSA patients against controls. The prevalence of the mutations were not significantly different between RSA patient and controls. In conclusion, our results show that inherited thrombophilia was not found to be associated with recurrent pregnancy loss on Saudi population.
Supervisor
:
Prof. Dr. Taha Abdullah Kumosani
Thesis Type
:
Master Thesis
Publishing Year
:
1432 AH
2011 AD
Co-Supervisor
:
Dr. Mohammed Hussain Alqahtani
Added Date
:
Tuesday, September 27, 2011
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
نوف عوده الشريف
Alshareef, Nouf Owdah
Researcher
Master
Files
File Name
Type
Description
30666.pdf
pdf
Back To Researches Page