Document Details

Document Type : Article In Journal 
Document Title :
Management of painful vaso-occlusive crisis of sickle cell anemia: Consensus opinion
Management of painful vaso-occlusive crisis of sickle cell anemia: Consensus opinion
 
Subject : Hematology 
Document Language : English 
Abstract : Sickle-cell disease (SCD) is a wide-spread inherited hemolytic anemia that is due to a point mutation, leading to the substitution of valine for glutamic acid, causing a spectrum of clinical manifestations in addition to hemolysis and anemia. Acute painful crisis is a common sequela that can cause significant morbidity and negatively impact the patient's quality of life. Remarkable improvements in the understanding of the pathogenesis of this clinical syndrome and the role of cell adhesion, inflammation, and coagulation in acute painful crisis have led to changes in the management of pain. Due to the endemic nature of SCD in various parts of the Middle East, a group of physicians and scientists from the United States and Middle East recently met to draw up a set of suggested guidelines for the management of acute painful crisis that are reflective of local and international experience. This review brings together a detailed etiology, the pathophysiology, and clinical presentation of SCD, including the differential diagnoses of pain associated with the disease, with evidence-based recommendations for pain management and the potential impact of low-molecular-weight heparin (LMWH), from the perspective of physicians and scientists with long-term experience in the management of a large number of patients with SCD 
ISSN : 1076-0296 
Journal Name : Clinical and Applied Thrombosis/Hemostasis 
Volume : 16 
Issue Number : 4 
Publishing Year : 1431 AH
2010 AD 
Article Type : Review Article 
Added Date : Thursday, August 11, 2011 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
سعاد الجاعونيAl-Jaouni, Soad ResearcherDoctorate 
محمد قاريQari, Mohammed ResearcherDoctorate 

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