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Faculty of Medicine
Document Details
Document Type
:
Article In Journal
Document Title
:
Successful treatment of chronic hepatitis C virus infection with peginterferon alpha-2a and ribavirin in patients with sickle cell disease
Successful treatment of chronic hepatitis C virus infection with peginterferon alpha-2a and ribavirin in patients with sickle cell disease
Subject
:
Infectious Diseases
Document Language
:
English
Abstract
:
The objective of this case series was to determine the efficacy and safety of combined treatment with ribavirin and peginterferon alpha-2a in sickle cell disease (SCD) patients with chronic hepatitis C virus (HCV) hepatitis. Eight patients in King Abdulaziz Hospital & Oncology Center, Jeddah, Kingdom of Saudi Arabia from 2003 and 2006 with chronic HCV infection were treated with peginterferon alpha-2a and ribavirin for one year. All 8 patients had a complete early virological response. Seven out of 8 had an end of treatment response with undetectable HCV RNA at the end of therapy, 5 of whom also maintained a sustained virological response when assessed 6 months after the end of treatment. Hemoglobin concentrations measured at one, 3, 6, 9, and 12 months of treatment showed no significant changes from that measured as baseline. Treatment of chronic HCV hepatitis in patients with SCD with peginterferon alpha-2a and ribavirin seems safe and effective
ISSN
:
0379-5284
Journal Name
:
The Saudi Medical Journal
Volume
:
30
Issue Number
:
5
Publishing Year
:
1430 AH
2009 AD
Article Type
:
Article
Added Date
:
Tuesday, August 2, 2011
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
عادل خزندار
Khazindar, Adil
Researcher
Doctorate
Files
File Name
Type
Description
29992.pdf
pdf
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