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Faculty of Medicine
Document Details
Document Type
:
Article In Journal
Document Title
:
Aminoglutethimide as an inducer of oxidative drug metabolism in the rat
Aminoglutethimide as an inducer of oxidative drug metabolism in the rat
Subject
:
Pharmacology
Document Language
:
English
Abstract
:
There is some evidence that when aminoglutethimide is used in the treatment of patients with advanced breast cancer a clinically-significant degree of hepatic enzyme induction may occur. This activity of the drug has been investigated in female rats. After three daily oral doses (60 mg/kg) of aminoglutethimide, the hypnotic effect of hexobarbitone was significantly shortened and plasma levels of dicoumarol were lowered. This pretreatment regimen also diminished an estradiol-induced increase in uterine weight. Electron microscopy of liver from aminoglutethimide-treated rats revealed a proliferation of smooth endoplasmic reticulum. There were significant increases in the metabolism of 4-nitroanisole, dicoumarol and [14C]estradiol by the 10,000 × g supernatant of liver homogenates from aminoglutethimide-pretreated rats. In these animals, levels of hepatic microsomal protein, cytochrome P-450 and NADPH-cytochrome-C reductase were raised. The results are consistent with aminoglutethimide being a phenobarbitone-like inducer of the hepatic mixed-function oxidases
ISSN
:
0163-7258
Journal Name
:
Pharmacology & Therapeutics
Volume
:
33
Issue Number
:
1
Publishing Year
:
1407 AH
1987 AD
Article Type
:
Article
Added Date
:
Thursday, March 31, 2011
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
زهير دمنهوري
Damanhouri, Zoheir
Investigator
Doctorate
Files
File Name
Type
Description
29439.pdf
pdf
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