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Faculty of Medicine
Document Details
Document Type
:
Article In Journal
Document Title
:
In-vivo effects of itraconazole on hepatic mixed-function oxidase
In-vivo effects of itraconazole on hepatic mixed-function oxidase
Subject
:
Pharmacology
Document Language
:
English
Abstract
:
The effects of itraconazole, a triazole antifungal agent, on cytochrome P450 were investigated by measuring the anti-convulsant activity of phenytoin in mice, and zoxazolamine paralysis time, tolbutamide clearance, and plasma dicoumarol concentrations after a single injection of dicoumarol, in rats. Itraconazole, given either as a single dose of 5 or 10 mg/kg, or daily at these levels for five days, had no significant effect on any of the measures. The drug therefore appears to be free of enzyme inhibiting or inducing activity, although an effect on other cytochrome P450 isozymes can not be discounted. Thus itraconazole may possibly show fewer clinically significant drug interactions at the level of hepatic mixed function oxidase than other azole antifungal agents
ISSN
:
1460-2091
Journal Name
:
The Journal of Antimicrobial Chemotherapy
Volume
:
21
Issue Number
:
2
Publishing Year
:
1408 AH
1988 AD
Article Type
:
Article
Added Date
:
Thursday, March 31, 2011
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
زهير دمنهوري
Damanhouri, Zoheir
Investigator
Doctorate
Files
File Name
Type
Description
29437.pdf
pdf
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