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Document Details
Document Type
:
Article In Journal
Document Title
:
Mixed function oxidases in kidney and duodenum of camel, guinea pig and rat
Mixed function oxidases in kidney and duodenum of camel, guinea pig and rat
Subject
:
Pharmacology
Document Language
:
English
Abstract
:
The activities of the drug-metabolizing enzymes, aniline 4-hydroxylase, benzphetamine N-demethylase and 7-ethoxycoumarin O-deethylase have been measured in vitro in kidneys and duodenum of camels (Camelus dromedarius), guinea pigs (Cavia porcellus) and rats (Rattus norvegicus). In these species, levels of hepatic microsomal parameters namely microsomal protein, cytochrome P(450), cytochrome b(5) and NADPH-cytochrome c reductase have also been determined. In general, camels seemed to have the lowest enzyme activity when compared to rats and guinea pigs. Rats showed the highest activity in NADPH-cytochrome c reductase, aniline 4-hydroxylase and ethoxycoumarin O-deethylase among these species. However, guinea pigs showed the highest enzyme activity in cytochrome P(450), cytochrome b(5) and benzphetamine N-demethylase
ISSN
:
1532-0456
Journal Name
:
Comparative Biochemistry and Physiology. Toxicology and Pharmacology
Volume
:
132
Issue Number
:
4
Publishing Year
:
1423 AH
2002 AD
Article Type
:
Article
Added Date
:
Thursday, March 31, 2011
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
زهير دمنهوري
Damanhouri, Zoheir
Researcher
Doctorate
Files
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Type
Description
29435.pdf
pdf
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