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Faculty of Medicine
Document Details
Document Type
:
Article In Journal
Document Title
:
Plasma and brain catecholamines in experimental uremia: acute and chronic studies
Plasma and brain catecholamines in experimental uremia: acute and chronic studies
Document Language
:
English
Abstract
:
To evaluate the role of catecholamines (CA) in uremia, we used "high performance" liquid chromatographic technique with electrodetection to determine plasma and brain concentration of dopamine (DA), norepinephrine (NE) and epinephrine (E) in rats with acute and chronic uremia. The results revealed a steady elevation in plasma CA (p less than 0.05) in both acutely and chronically uremic rats when compared to the level of these neurotransmitters in controls. The highest changes were observed in DA and the least in NE (16.8 +/- 3.2 vs. 0.5 +/- 0.2 ng/ml and 93.2 +/- 11.1 vs. 68.1 +/- 16.3 ng/ml). There was a positive correlation between plasma CA and the duration of uremia (r = 0.97; p less than 0.05). The elevations were more pronounced in acutely uremic rats than in chronically uremic rats. This was followed by a concomitant depletion in the concentration of DA, NE and E in the brain. The defects in catecholaminergic neurotransmission as evidence of dysfunction in the autonomic nervous system may contribute to the development of neuropathy
ISSN
:
0024-3205
Journal Name
:
Life Sciences
Volume
:
37
Issue Number
:
19
Publishing Year
:
1415 AH
1985 AD
Article Type
:
Article
Added Date
:
Thursday, March 31, 2011
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
أسامة طيب
Tayeb, Osama
Researcher
Doctorate
Files
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Description
29431.pdf
pdf
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