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Faculty of Medicine
Document Details
Document Type
:
Article In Journal
Document Title
:
Correlation between predicted and measured digoxin serum concentrations
Correlation between predicted and measured digoxin serum concentrations
Subject
:
Pharmacology
Document Language
:
English
Abstract
:
Measurement of digoxin serum concentration can be useful as a direct guide to the dose appropriate to individual patients. Therefore, we have attempted to predict digoxin serum concentration in 62 patients with a wide range of body weight, age and renal function, using creatinine clearance and individual digoxin dose. Creatinine clearance in each patient was determined by the Cockroft and Gault method (1). Digoxin clearance was determined by Scheiner's method (2). Once digoxin clearance was determined, the predicted steady-state serum concentration was calculated using general pharmacokinetic principles. Each patient was on digoxin therapy for at least 1 month. Digoxin serum concentration was measured by the newly developed fluorescence polarization immunoassay (FPIA). A linear regression analysis was performed on the data from the predicted and measured serum level which yielded a slope of 0.9463, intercept of 0.0950 and a correlation coefficient (r) of 0.9600. The method was found to be very useful to predict digoxin serum levels in overdosed and underdosed patients
ISSN
:
1365-2710
Journal Name
:
Journal of Clinical Pharmacy and Therapeutics
Volume
:
13
Issue Number
:
2
Publishing Year
:
1408 AH
1988 AD
Article Type
:
Article
Added Date
:
Wednesday, March 30, 2011
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
أسامة طيب
Tayeb, Osama
Investigator
Doctorate
سميرة اسلام
Islam, Samira
Researcher
Doctorate
Files
File Name
Type
Description
29427.pdf
pdf
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