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Faculty of Medicine
Document Details
Document Type
:
Article In Journal
Document Title
:
A serious interaction of dantrolene and theophylline
A serious interaction of dantrolene and theophylline
Subject
:
Pharmacology
Document Language
:
English
Abstract
:
Dantrolene and theophylline have in common pronounced actions on several muscular systems. Therefore we investigated the interaction of these 2 drugs in rats. Normal cases of dantrolene (4 or 2 mg/kg) caused an increase in the lethality produced by theophylline, but without showing the expected seizures of theophylline toxicity. This may be caused by a synergistic action on the heart or blood vessels. On the other hand, a small dose of dantrolene decreased theophylline-induced seizures and death. This may be due to the effect of dantrolene on calcium release in skeletal muscles. The dosage of dantrolene should be decreased when used with theophylline
ISSN
:
0145-6296
Journal Name
:
Veterinary and Human Toxicology
Volume
:
32
Issue Number
:
5
Publishing Year
:
1410 AH
1990 AD
Article Type
:
Article
Added Date
:
Wednesday, March 30, 2011
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
أسامة طيب
Tayeb, Osama
Researcher
Doctorate
Files
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Description
29424.pdf
pdf
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