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Faculty of Medicine
Document Details
Document Type
:
Article In Journal
Document Title
:
A comparative study of liver mixed function oxidases in camels (Camelus dromedarius), guinea pigs (Cavia porcellus) and rats (Rattus norvegicus)
A comparative study of liver mixed function oxidases in camels (Camelus dromedarius), guinea pigs (Cavia porcellus) and rats (Rattus norvegicus)
Subject
:
Pharmacology
Document Language
:
English
Abstract
:
1. The activities of the drug-metabolizing enzymes, benzphetamine N-demethylase, 7-ethoxycoumarin O-deethylase and dicoumarol oxidation have been measured in vitro in the liver of camels, guinea pigs and rats. 2. In these species, levels of hepatic microsomal parameters namely microsomal protein, cytochrome P450, cytochrome b5 and NADPH-cytochrome c reductase have also been determined. 3. In general, camels seemed to have the lowest enzyme activity when compared to rats and guinea pigs. 4. Some sex differences were observed in the levels of enzymes studied. In rats and guinea pigs, males had higher benzphetamine N-demethylase than females. However, in camels and guinea pigs, females had higher 7-ethoxycoumarin O-deethylase when compared to males
ISSN
:
1532-0456
Journal Name
:
Comparative Biochemistry and Physiology. Comparative Pharmacology and Toxicology
Volume
:
105
Issue Number
:
3
Publishing Year
:
1413 AH
1993 AD
Article Type
:
Article
Added Date
:
Wednesday, March 30, 2011
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
زهير دمنهوري
Damanhouri, Zoheir
Investigator
Doctorate
أسامة طيب
Tayeb, Osama
Researcher
Doctorate
Files
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Type
Description
29420.pdf
pdf
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