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Faculty of Medicine
Document Details
Document Type
:
Article In Journal
Document Title
:
Comparison of cytochrome P-450 content and conjugative enzymes in livers of camels (Camelus dromedarius), guinea-pigs (Cavia porcellus) and rats (Rattus norvegicus)
Comparison of cytochrome P-450 content and conjugative enzymes in livers of camels (Camelus dromedarius), guinea-pigs (Cavia porcellus) and rats (Rattus norvegicus)
Subject
:
Pharmacology
Document Language
:
English
Abstract
:
The activities of the conjugative enzymes, glutathione S-transferase and UDP-glucuronyl-transferase, have been measured in vitro in the livers of camels, guinea-pigs and rats. Some sex differences were observed in the levels of these conjugative enzymes. In rats and guinea-pigs, females had higher UDP-glucuronyltransferase activity than males. In camels, females had higher glutathione S-transferase activity than males. In these species, the cytochrome P-450 isozymes observed between the 50,000 and 60,000 mol. wt regions have been separated and characterized by SDS-polyacrylamide gel electrophoresis. Camels showed lower levels of all types of cytochrome P-450 isozymes, while guinea-pigs showed higher levels of most of these isozymes. In general, camels seemed to have the lowest drug-metabolizing enzyme activity when compared to rats and guinea-pigs
ISSN
:
1096-4959
Journal Name
:
Comparative Biochemistry and Physiology. Biochemistry and Molecular biology
Volume
:
108
Issue Number
:
3
Publishing Year
:
1414 AH
1994 AD
Article Type
:
Article
Added Date
:
Wednesday, March 30, 2011
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
زهير دمنهوري
Damanhouri, Zoheir
Investigator
Doctorate
أسامة طيب
Tayeb, Osama
Researcher
Doctorate
Files
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Type
Description
29419.pdf
pdf
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