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Faculty of Medicine
Document Details
Document Type
:
Article In Journal
Document Title
:
Characterization of the heat-released substance from rat ileal muscle
Characterization of the heat-released substance from rat ileal muscle
Subject
:
Pharmacology
Document Language
:
English
Abstract
:
Previous studies have proposed that increasing the temperature around the rat isolated ileal muscles induces a heat-released substance (HRS) which causes a decrease in the contractile response. Therefore, we have studied various characteristics of this proposed HRS in animals exposed to heat-stress conditions. In these animals, the contraction of muscles in response to carbachol was decreased by increasing the temperature from 37 degrees C to 40 degrees C. Further, bathing the ileum in a conditioned medium prepared by incubation of the ileal muscle at 40 degrees C has shown less contraction at 40 degrees C than in presence of normal Krebs medium. In addition, conditioned mediums, prepared at 40 degrees C were run on SDS-polyacrylamide gel electrophoresis and have shown the presence of a distinct protein band at a m.w. region of 55 kDa. These results confirm our previous studies that increasing the temperature around the muscles induces the HRS that causes the decrease in the contractile response
ISSN
:
1232-1966
Journal Name
:
Annals of Agricultural and Environmental Medicine
Volume
:
6
Issue Number
:
2
Publishing Year
:
1419 AH
1999 AD
Article Type
:
Article
Added Date
:
Wednesday, March 30, 2011
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
زهير دمنهوري
Damanhouri, Zoheir
Investigator
Doctorate
أسامة طيب
Tayeb, Osama
Researcher
Doctorate
Files
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Type
Description
29417.pdf
pdf
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