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Faculty of Medicine
Document Details
Document Type
:
Article In Journal
Document Title
:
Regenerative failure of diabetic nerves bridging transection injuries
Regenerative failure of diabetic nerves bridging transection injuries
Subject
:
Neurosurgery
Document Language
:
English
Abstract
:
BACKGROUND: Failed regeneration compounds the deficits imposed by diabetes from peripheral neuropathy. In this work, we addressed how diabetes or local glucose toxicity might impact peripheral nerve trunk regeneration and reconstitution across major sciatic nerve transection injuries of rats. METHODS: Specific conduits, amendable to manipulation of infused glucose concentrations through a T connection, were perfused with 5 or 30 mmol/L glucose in nondiabetics or 5 mmol/L glucose in rats with experimental diabetes. Quantitative early and later regenerative outgrowth was measured. RESULTS: Local glucose exposure had no impact on early axon or Schwann cell outgrowth or partnering nor later myelinated axon regeneration. Despite only mildly attenuated early sprouting of axons with Schwann cells, diabetic bridges exhibited massive later failure of reconstitution by 3 weeks after injury. CONCLUSION: Diabetes is associated with severe limitations in regenerative success, despite appropriate early axon outgrowth
ISSN
:
1520-7552
Journal Name
:
Diabetes / Metabolism Research and Reviews
Volume
:
23
Issue Number
:
6
Publishing Year
:
1428 AH
2007 AD
Article Type
:
Article
Added Date
:
Sunday, March 20, 2011
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
محمد بنقش
Bangash, Mohammed
Researcher
Doctorate
Files
File Name
Type
Description
29325.zip
zip
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