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Faculty of Science and Arts - Khulais
Document Details
Document Type
:
Article In Journal
Document Title
:
Evaluation of the efficacy of RO 15-9268 against the Egyptian strain of Schistosoma mansoni in mice and the study of its effect on the activity of certain serum enzymes
تقييم الفاعلية العلاجية للعقار الجديد RO 15-9268 في الفئران المصابة ببلهارسيا المستقيم
Document Language
:
Arabic
Abstract
:
The oral administration of RO 15-9268 (12.5 mg/kg body weight) to Schistosoma manson- infected mice 7 wk post exposure to cercariae (120 cercariae/ mouse) led to a significant reduction in worm burden ( 89.80%) in liver and portomesentric veins concurrent with a hepatic shift at the 2nd wk post treatment followed by complete dis appearance of worms, 4 wk post-medication. The infection-induced increments in the activities of serum ASAT, ALAT and ALP were markedly reduced after the treatment with RO 15-9268 indicating the recovery of hepatic tissue post-stopping of ova position and eradication of parasite.When normal animals were administered RO 15-9268, no significant alterations were observed in the activities of serum ASAT, ALAT or ALP through 6 wk post treatment. This may indicate that RO-15-9268 in its chosen dosage level has no deleterious effects on liver tissue
ISSN
:
1319-0989
Journal Name
:
Arts and Humanities Journal
Volume
:
5
Issue Number
:
24
Publishing Year
:
1417 AH
1997 AD
Article Type
:
Article
Added Date
:
Monday, January 3, 2011
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
سيد محمد راوي
Rawi, sayed mohamed
Researcher
Doctorate
rawisayed@yahoo.com
Files
File Name
Type
Description
28439.pdf
pdf
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