Document Details

Document Type : Project 
Document Title :
The effect of pulpal and periodontal diseases on the general health
تأثير أمراض العصب وما حول ذروة السن وأمراض اللثة على صحة القلب والأوعية الدموية.
 
Subject : The effect of pulpal and periodontal diseases on the general health 
Document Language : Arabic 
Abstract : Several parameters of systemic inflammation have been identified as markers for cardiovascular disease. For example, levels of C-reactive protein (CRP) in the range 1 to 3 mg//L have recently gained special attention as risk factors for cardiac and cerebrovascular events. Also elevated plasma levels of interleukin-6 (IL-6) have been associated with unstable angina and cardiovascular diseases and IL-6 is related to other cardiovascular risk factors. Moreover, it has been established that IL-6 induces CRP. Furthermore, numbers of leukocytes have been associated with cardiovascular diseases. It has been proposed that elevated CRP, IL-6 and leukocytes in patients with cardiovascular disease may be the result of chronic infectious and inflammatory disease. One of the most common and often undiagnosed diseases of humans is periodontitis. This is a chronic infection of the supporting tissues of the teeth. Ity is estimated that about 30% of subjects >50 years have severe periodontitis. Periodontal disease is a chronic inflammatory process that occurs in response to a predominantly Gram-Negative bacterial infection originating from dental plaque. On the other hand endodontic diseases are caused by polymicrobial infections invading the dental pulp. Upon bacterial entry, pulpal necrosis ensues with the subsequent extension to the apical portion of the periodontal apparatus. Inflammatory lesions of the dental pulp are characterized by their chronic nature and their contamination with bactgeria and bactgerial by-products from the dead space of the dental pulp. Since both of these odontogenic lesions are within a direct contact with the body circulation. They have been implicated as nedi of infection and source for sepsis. Consequently, if a relationship exists between periodontal disease and systemic CRP within the population at large, it has the potential for substantial clinical relevance in helping to explain circumstances in which an intra-oral source of infection can create a systemic inflammatory response, therefore placing "apparently healthy" patients at increased risk of cardiovascular disease. Such an association could also represent a mechanism underlying recent epidemiological findings that oral diseases appear to be risk factors for cardiovascular disease. The purpose of this study is to characterize the relationship – if any – between systematic health local odontogenic lesions by tracing some molecular markers in blood samples from patients before and after treatment of these foci of infection. 
Publishing Year : 1427 AH
2006 AD 
Sponsor Name : King Abdulaziz University 
Sponsorship Year : 1427 AH
2006 AD 
Added Date : Wednesday, June 30, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
فهد حسن بانصرBanasr, Fahad HasanInvestigatorDoctorate 

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