Document Details

Document Type : Project 
Document Title :
The prognostic value of heat shock protein in breast cancer
الأهمية الإنذارية لبروتينات الصدمة الحرارية 27 و 70 كيلو دالتون في مرضى سرطان الثدي.
 
Subject : The prognostic value of heat shock protein in breast cancer 
Document Language : Arabic 
Abstract : Heat shock proteins (HSPs) first were defined as proteins induced by heat shcok and other environmental and pathophysiologic stresses and are implicated in protein-protein interactions such as folding, translocation, and prevention of inappropriate protein aggregation. Many of their functions suggest that they play important roles in cancer. They are overexpressedin a wide range of human cancers and are implicated in tumor cell proliferation, differentiation, invasion, metastasis, death and recognition by the immune system. The small heat shcock proteinhsp27 is often expressed at high levels in clinical breast tumors; however, its biological role in this disease still remains unclear. Several investigators have recently shown that hsp27 expression is associated with aggressive tumor behavior. Increased hsps expression may also predict the response to some anticancer treatments. For example, Hsp27 and Hsp70 are implicated in resistance to chemotherapy in breast cancer cells growing in vitro and in vivo. In several human carcinomas, hsp27 expression might also be related to wsorse prognosis. Heat shcok proteins (Hsps) are induced in vitro by several cytotoxic drugs; in human breast cancer cells these proteins appear to be involved in anti-cancer drug resistance. The present research proposal designed to evaluate the prognostic value of two hsps (hsp27 and hsp70) expression in 40 biopsies from breast cancer patients and to correlate their expression with clinical and histopathological parameters uysing the Chi-square test. The expression of the two hsps will be determined in Paraffin embedded sections immunohistochemically by staining with monoclonal antibodies against hsp27 & hsp70 and by Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR) using synthetic primers from the untranslated region of the two hsps genes. 
Publishing Year : 1427 AH
2006 AD 
Sponsor Name : King Abdulaziz University 
Sponsorship Year : 1427 AH
2006 AD 
Added Date : Monday, June 28, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
هاني زكريا عصفورAsfour, Hani ZakriyaInvestigatorDoctorate 

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