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Document Details
Document Type
:
Article In Journal
Document Title
:
Study of ochratoxin A as an nvironmental risk that causes renal injury in breast-fed Egyptian infants
Study of ochratoxin A as an nvironmental risk that causes renal injury in breast-fed Egyptian infants
Document Language
:
English
Abstract
:
Ochratoxin A (OTA) constitutes a real human threat. Its presence in human milk has previously been reported in different countries. This study is the first Egyptian report on the presence of OTA in both mothers’ milk and infants’ sera, addressing its correlation with infants’ kidney functions, which was not previously addressed in the literature. Fifty healthy breast-lactating mothers and their infants who were exclusively breast-fed for at least 4 months were included. All of them were subjected to a thorough laboratory evaluation including determination of OTA concentration by high-performance liquid chromatography. Thirty-six mothers (72%) and their infants had been contaminated with OTA. Univariate analysis showed that the presence of OTA was associated with significantly higher levels of urinary b2 microglobulin and microalbuminuria. Multivariate logistic regression analysis showed that there was a significant correlation between a higher OTA level in infants’ sera and the degree of microalbuminuria. Mothers and their infants in our locality are exposed to a high OTA contamination rate (72%). To establish the role of OTA in causation of future renal dysfunction for infants, large controlled studies are warranted.
ISSN
:
0931-041X
Journal Name
:
Pediatr Nephrol
Volume
:
1
Issue Number
:
21
Publishing Year
:
1426 AH
2006 AD
Article Type
:
Article
Added Date
:
Saturday, May 15, 2010
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
أسامة جابر
Gaber, Osama
Researcher
Doctorate
Files
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Type
Description
26664.doc
doc
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