Main Page
Faculty Deanship
Dean
Health Empowerment Unit
Strategic Planning Unit
Development and Quality Unit
Medical and Bioethics Unit
Vice Dean for Graduate Studies and Research
Vice Dean for Female Section
Vice dean for Academic Affairs
Examination and Assessment Unit
Internship and Alumni Unit
Student Research Unit
E-learning Unit
Student Mentoring and Support Unit
Community Service Unit
Talent and Creativity Care Unit
Continuing Education Unit
Neuroscience Research Unit
Vice Deanship of Clinical Affairs / Administration
Organizational Structure
Departments
Basic Sciences
Department of Anatomy
Department of Pharmacology
Department of Pathology
Department of Microbiology and Medical Parasitolog
Deparment of Clinical Biochemistry
Department of Physiology
Department of Medical Genetics
Clinical Sciences
Department of Otorhinolaryngology
Department of Obstetrics and Gynecology
Department of Hematology
Department of Medical Education
Department of Anesthesia
Department of Family Medicine
Department of Community Medicine
Department of Surgery
Department of Orthopedic Surgery
Department of ophthalmology
Department of Radiology
Department of Internal Medicine
Department of Pediatrics
Department of Emergency Medicine
Department of Urology
Department of Dermatology
Latest News
عربي
English
About
Admission
Academic
Research and Innovations
University Life
E-Services
Search
Faculty of Medicine
Document Details
Document Type
:
Article In Journal
Document Title
:
Effects of H2-receptor blocker (Ranitidine) on duodenal motility of Rats
Effects of H2-receptor blocker (Ranitidine) on duodenal motility of Rats
Document Language
:
English
Abstract
:
In this study the effect of ranitidine, a well known H-2 receptor antagonist, on duodenal motility was investigated. 28 male albino rats were classified into 3 groups, 12 rats used as a control group, 8 rats injected with single dose of ranitidine and a third group of 8 rats received daily IP injection of ranitidine for one week. In vitro effects of ranitidine were also recorded. The response to ranitidine infusion in-vitro showed significant increase in both average force of duodenal contraction and the motlity index compared to their basal values. On the other hand the frequency of duodenal contractions and the average duration were not significantly changed with ranitidine infusion compared to the basal values. The addition of ranitidine after atropinization was still associated with significant increase in average force of contraction and motility index as compared to basal values. Although the degree of significance has decreased after addition of atropine compared with that before atropinization. In addition, ranitidine infusion augments the stimulatory effects of histamine on duodenal motility suggesting that ranitidlne has some histamine receptor agonistic action. In-vivo study showed also that injection of ranitidine as a single dose was associated with significant increase in the average force of contraction of the duodenum of injected rats compared to control group. Also, there was significant increase in motility index of single dose ranitidine injected rats. On the other hand, the freqwency of contractions and the average duration of contraction were not significantly altered. Similarly, rats daily injected with ranitidine for one week exhibited a similar motility pattern with higher degree of significance It could be concluded that, the H2 receptor antagonist (ranitidine) has a clear contractile effect on rat duodenum an effect that may be attributed to direct effect, a partial cholinergic effect and may be related to gastric acid suppression.
ISSN
:
3189-4528
Journal Name
:
Zagazig University Medical Journal
Volume
:
5
Issue Number
:
4
Publishing Year
:
2004 AH
2004 AD
Article Type
:
Article
Added Date
:
Sunday, March 21, 2010
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
عاطف موسى عبود
Abood, Atef M
Researcher
Doctorate
Files
File Name
Type
Description
26125.3
3
Back To Researches Page