Main Page
About Science
Faculty Deanship
Letter of Dean
Overview of Deanship
Vice Deans
Vice Dean
Letter of Vice-dean
Overview of Vice-deanship
Vice Dean for Graduate Studies
Letter of Vice Dean for Graduate Studies
Overview of Vice Dean of Postgraduate Studies
Research and Innovation Unit
Vice Dean for Girls Campus
Faculty Management
Letter of Managing Director-Boys Campus
Letter of Managing Director-Girls Campus
Overview of Management
Educational Affairs
Males Campus
Staff
Females Campus
Contact Us
Research
عربي
English
About
Admission
Academic
Research and Innovations
University Life
E-Services
Search
Faculty of Sciences
Document Details
Document Type
:
Article In Journal
Document Title
:
Urinary NAG, AAP and Microalbuminuria as Indicators of Hypertensive Disease
المؤشرات الأنزيمية (NAG , AAP) والميكروإلبيومين يوريا في بول مرضى السكر ذوي الضغط المرتفع
Subject
:
Biochemistry
Document Language
:
English
Abstract
:
In the current study certain kidney biochemical markers were measured in the urine of Saudi patients suffering from diabetes mellitus. Two enzyme markers, N-acetyl-?-D-glucosaminidase (NAG), a lysosomal enzyme in the catalysis of glycoprotein and alanine aminopeptidase (AAP) a brush border enzyme of the proximal tubules involved in amino acid metabolism, have been reported to be sensitive indicators of renal damage. The established marker, microalbuminuria was also measured, as it is productive of overt nephropathy and renal diseases. The results showed that in diabetes mellitus high levels of urinary NAG activity were associated with high microalbuminuria and elevated AAP levels; NAG activity was high in the normotensive IDDM patients. Microalbuminuria was higher in hypertensive patients than in normotensive patients. In hypertensive patients lower total protein values were associated with IDDM but not with NIDDM. NAG assay, AAP and microalbuminuria may be useful markers for early detection of kidney damage and as an alternative measurements for renal dysfunction, although they may not be useful in diagnosing late stage of kidney failure.
ISSN
:
1012-1319
Journal Name
:
Science Journal
Volume
:
20
Issue Number
:
1
Publishing Year
:
2008 AH
2008 AD
Article Type
:
Article
Added Date
:
Tuesday, February 2, 2010
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
سهيرة أحمد لاري
Lary, Sahirah A
Researcher
Doctorate
slary@kau.edu.sa
Files
File Name
Type
Description
25029.pdf
pdf
Abstract
Back To Researches Page