Main Page
Faculty Deanship
Dean
Health Empowerment Unit
Strategic Planning Unit
Development and Quality Unit
Medical and Bioethics Unit
Vice Dean for Graduate Studies and Research
Vice Dean for Female Section
Vice dean for Academic Affairs
Examination and Assessment Unit
Internship and Alumni Unit
Student Research Unit
E-learning Unit
Student Mentoring and Support Unit
Community Service Unit
Talent and Creativity Care Unit
Continuing Education Unit
Neuroscience Research Unit
Vice Deanship of Clinical Affairs / Administration
Organizational Structure
Departments
Basic Sciences
Department of Anatomy
Department of Pharmacology
Department of Pathology
Department of Microbiology and Medical Parasitolog
Deparment of Clinical Biochemistry
Department of Physiology
Department of Medical Genetics
Clinical Sciences
Department of Otorhinolaryngology
Department of Obstetrics and Gynecology
Department of Hematology
Department of Medical Education
Department of Anesthesia
Department of Family Medicine
Department of Community Medicine
Department of Surgery
Department of Orthopedic Surgery
Department of ophthalmology
Department of Radiology
Department of Internal Medicine
Department of Pediatrics
Department of Emergency Medicine
Department of Urology
Department of Dermatology
Latest News
عربي
English
About
Admission
Academic
Research and Innovations
University Life
E-Services
Search
Faculty of Medicine
Document Details
Document Type
:
Article In Journal
Document Title
:
The Relationship of Opioid Analgesia to Quality of Life in an Adult Sickle Cell Population
The Relationship of Opioid Analgesia to Quality of Life in an Adult Sickle Cell Population
Subject
:
medical research
Document Language
:
English
Abstract
:
Objective: To determine the relationship of opioid analgesia to quality of life in adults with sickle cell. Design: Data were collected by patient interviews and review of medical records. The Medical Outcome Study 36-item Short Form (SF36) was used to determine quality of life. Setting: Duke Comprehensive Sickle Cell Center. Patients: 185 out-patients with various genotypes of sickle cell disease. Main Outcome Measure: Quality of life as measured by the SF36. Results: Quality of life outcomes were not lower in individuals with the classically more severe homozygous SS when compared to the heterozygous SC. SF36 scores were significantly lower in individuals who were on opioids alone or on opioids and hydroxyurea concurrently, as compared to those who were either on no medications or on hydroxyurea alone. Disease severity scores were not significantly different between groups. When controlling for hydroxyurea use, the negative association between opioid use and SF36 scores remained unchanged. Conclusions: Sickle cell patients using opioids daily had significantly poorer quality of life than those who were not on opioids. Disease severity scores were not significantly different in the two patient groups. Prospective studies are needed to define the relationship of opioid use to quality of life in sickle cell disease and opioid interaction with hydroxyurea.
ISSN
:
1877-1319
Journal Name
:
Health Outcome Research in Medicine
Volume
:
1
Issue Number
:
1
Publishing Year
:
1431 AH
2010 AD
Article Type
:
Article
Added Date
:
Wednesday, September 9, 2009
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
سهير آدم
Adam, Soheir
Investigator
Doctorate
soheir.adam@duke.edu
Files
File Name
Type
Description
20637.doc
doc
Back To Researches Page