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Document Details
Document Type
:
Article In Journal
Document Title
:
Randomized Clinical Trial to Evaluate the Safety of Avoiding Pre-operative Transfusion in Sickle Cell Anemia
Randomized Clinical Trial to Evaluate the Safety of Avoiding Pre-operative Transfusion in Sickle Cell Anemia
Document Language
:
English
Abstract
:
Background: Patients with sickle cell anemia have an increased chance of undergoing surgical procedures with higher morbidity. The practice of pre-operative blood transfusion for such patients is still controversial. Objective: The aim of the study was to evaluate and assess the safety of avoiding pre-operative transfusions in patients with sickle cell anemia. Design: Prospective randomized clinical trial. Setting: Surgical departments, King Abdulaziz University Hospital and King Fahed Armed Forces Hospital in Jeddah. Method: A randomized clinical trial of 369 sickle cell anemic patients with a median age of 16 years old (range: 1-35 years old), underwent surgical procedures between November 1996 and November 2001. Surgical procedures included adenoidectomy, tonsillectomy, total hip arthroplasty, cholecystectomy, splenectomy, and Obstetric and Gynecological surgeries. Patients with stable clinical and hematological state were randomized into two groups: Group I (n=181), received no pre-operative transfusion and Group II (n=188) received simple or partial exchange transfusion pre-operatively. All patients were carefully hydrated and good oxygenation was maintained. Result: None of the patients developed major intra or postoperative complications in both groups. Fourteen percent of the pre-operative transfusion group developed postoperative complications versus 7% in non-transfused group with a significant P value (0.002). Conclusion: Avoidance of pre-operative transfusion is a safe practice in properly selected steady state sicklers. On the contrary, it is believed that the risks associated with transfusion were avoided
ISSN
:
1012-8298
Journal Name
:
Bahrain Medical Bulleting
Volume
:
28
Issue Number
:
4
Publishing Year
:
1427 AH
2006 AD
Article Type
:
Article
Added Date
:
Sunday, August 30, 2009
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
سعاد الجاعوني
Al-Jaouni, Soad
Investigator
Doctorate
سعد المحياوي
Al-Muhayawi, Saad
Researcher
Doctorate
محمد قاري
Qari, Mohammed
Researcher
Doctorate
عدنان المزروع
Al-Mazrooa, Adnan
Researcher
Doctorate
Files
File Name
Type
Description
29040.pdf
pdf
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