Document Details

Document Type : Thesis 
Document Title :
INFLUENCE OF OBESITY ON HUMAN FEMALES HEART RATE VARIABILITY
تأثير السمنة على معدلات الاختلاف في نبضات القلب
 
Subject : INFLUENCE OF OBESITY ON HUMAN FEMALES HEART RATE VARIABILITY 
Document Language : Arabic 
Abstract : Obesity is becoming a global epidemic in both children and adults. It is associated with numerous morbidities such as cardiovascular diseases (CVD), type 2 diabetes, hypertension, certain cancers and sleep apnea. Obesity is associated with an increased risk of morbidity and mortality as well as reduced life expectancy. Obesity may affect the heart through its influence on known risk factors such as dyslipidemia, hypertension, glucose intolerance inflammatory markers, obstructive sleep apnea, hypoventilation. In addition preobese and obesity predispose to or are associated with numerous cardiac complications such as coronary heart disease, heart failure and sudden death because of their impact on the cardiovascular system. Obese subjects were shown to have wide inter-individual variation in their heart rate behavior. Heart rate variability is the amount of the heart fluctuations around the mean of the heart rate. It can be used as mirror of the Cardio-respiratory Control System. Heart rate variability analysis provides insight into autonomic function and has abroad applications in human physiology. A fluctuation between normal beat to beat intervals occurs because they are mediated by autonomic input to the sinus node, which provides information about cardiac autonomic modulation. Power lab system was used to measure simultaneously the short term HRV in 42 normotensive females aged (20 to 30 years) after three hours from fatty meal ingestion which increase sympathetic activity. Subjects subdivided into 3 groups: (1) control group (Body mass index [BMI] is between (18:50-24:99 kg/m2) n=13; (2) preobese group BMI (25- 29,99 kg/m2) n=13; (3) obese group BMI (  30 kg/m2) n=16. Short term HRV was analyzed by 15- minute period of standardized ECG recording in using time and frequency domain measure of Power lab system. Large inter individual variation was observed in the measure of HRV in young-aged female subjects of medical college in king Abdulaziz University. Our study clarified that the Sympathetic activation by fatty meal is decreased in obese subjects also there was a decreased responsiveness of the cardiovascular System to parasympathetic activity in obese subjects. In addition, the total power was decreased in obese persons. The very low frequency (VLF) waves were significantly decreased in obese group. Also, there was a positive significant correlation between WHR and SBP in the obese individuals indicating that by time the obese subjects will be exposed to the complication of hypertension. Our results also showed that fatty meal ingestion and the related hyperinsulemia caused a marked increase in LF and HF Power of HRV in preobese subjects. Both the sympathetic and the parasympathetic nervous system were stimulated by this meal. So doctors should be clarifying the complication of obesity for their obesity patients and those patients should be exerting effort to decrease their weight before complications of obesity occur. 
Supervisor : PROF.DR. 
Thesis Type : Master Thesis 
Publishing Year : 1429 AH
2008 AD 
Co-Supervisor : dr. 
Added Date : Monday, May 4, 2009 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
خديجة مسعد السلميAL SOLAMI, KHADEEJAH MESAIDResearcherMaster 

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