Document Details

Document Type : Article In Journal 
Document Title :
Cytokine changes in patients with heatstroke during pilgrimage to Makkah
Cytokine changes in patients with heatstroke during pilgrimage to Makkah
 
Subject : Internal Medicine 
Document Language : English 
Abstract : Circulating levels and role of IL-6, IL-1ra, TNFsr-II and CRP in patients with heatstroke is not fully known. This study correlated levels of these mediators with outcome in 26 patients. In survivors (n=20), IL-6 concentration declined on cooling, whereas in non-survivors levels continued to increase at 6 h following admission before declining. Admission TNFsr-II concentrations in survivors were significantly lower than non-survivors and levels continued to rise in both groups. IL-1ra levels were markedly elevated in both groups. Changes in cytokine levels were not influenced by renal function. Elevated C-reactive protein levels were observed for both groups and remained so despite cooling, furthermore, there was no correlation with alanine aminotransferase levels. The study demonstrated the elevation of the above mediators and suggested a role in the pathogenesis of heatstroke. Markedly elevated levels or those that remained elevated despite cooling were associated with mortality 
ISSN : 0962-9351 
Journal Name : Mediators of Inflammation 
Volume : 6 
Issue Number : 2 
Publishing Year : 1418 AH
1997 AD 
Article Type : Article 
Added Date : Monday, May 12, 2008 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
سعد الشهيبAl-Shohaib, Saad ResearcherDoctorate 
محمود الاحولAl-Ahwal, Mahmoud ResearcherDoctorate 

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